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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站

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Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. 
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. 
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. 
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. 
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. 
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。    中新网8月26日电 8月26日，国务院台办举行例行新闻发布会。有记者问：近日，台湾各地地检署陆续寄给辖区里长选举查察宣导信，包含“大陆介选”“不能违反反渗透法”等内容，岛内舆论认为这是“假宣导之名、行恐吓之实”，陆委会声称“是很有必要的”。请问对此有何评论？          　　国台办发言人张晗表示，每逢岛内选举，民进党就刻意操弄“抗中保台”、诬蔑“大陆介选”，以谋取政治私利。这次又不惜动用检调机关和司法手段威胁恐吓民众、大肆制造“绿色恐怖”。民进党这种卑劣的做法已经被越来越多的台湾民众看穿和唾弃。(中新网“燕新台”工作室)                【编辑:张令旗】。

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